Your Health
12:13 PM - Public
Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome.
Omeprazole is a competitive inhibitor of the enzymes CYP2C19 and CYP2C9, and may therefore interact with drugs that depend on them for metabolism, such as diazepam, escitalopram, and warfarin.
Drugs that depend on stomach pH for absorption may interact with omeprazole; drugs that depend on an acidic environment (such as ketoconazole or atazanavir) will be poorly absorbed, whereas acid-labile antibiotics (such as erythromycin) will be absorbed to a greater extent than normal due to the more alkaline environment of the stomach.
St. John's wort (Hypericum perforatum) and Gingko biloba significantly reduce plasma concentrations of omeprazole through induction of CYP3A4 and CYP2C19
http://en.wikipedia.org/wiki/Omeprazole
Omeprazole is a competitive inhibitor of the enzymes CYP2C19 and CYP2C9, and may therefore interact with drugs that depend on them for metabolism, such as diazepam, escitalopram, and warfarin.
Drugs that depend on stomach pH for absorption may interact with omeprazole; drugs that depend on an acidic environment (such as ketoconazole or atazanavir) will be poorly absorbed, whereas acid-labile antibiotics (such as erythromycin) will be absorbed to a greater extent than normal due to the more alkaline environment of the stomach.
St. John's wort (Hypericum perforatum) and Gingko biloba significantly reduce plasma concentrations of omeprazole through induction of CYP3A4 and CYP2C19
http://en.wikipedia.org/wiki/Omeprazole
Your Health
12:07 PM - Public
the most frequent side effects of omeprazole (experienced by over 1% of those taking the drug) are headache, diarrhea, abdominal pain, nausea, dizziness, trouble awakening and sleep deprivation, ''
Other side effects may include iron and vitamin B12 deficiency
Proton pump inhibitors may be associated with a greater risk of osteoporosis related fractures and Clostridium difficile-associated diarrhea
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000936/
Other side effects may include iron and vitamin B12 deficiency
Proton pump inhibitors may be associated with a greater risk of osteoporosis related fractures and Clostridium difficile-associated diarrhea
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000936/
Your Health
12:00 PM - Public
Prilosec OTC (over-the-counter) should be taken only once every 24 hours for 14 days. It may take up to 4 days for full effect. Do not take more than one tablet every 24 hours.
Taking a proton pump inhibitor such as omeprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older.
FDA pregnancy category C. It is not known whether omeprazole will harm an unborn baby.
Omeprazole can pass into breast milk and may harm a nursing baby.
http://www.drugs.com/omeprazole.html
Taking a proton pump inhibitor such as omeprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older.
FDA pregnancy category C. It is not known whether omeprazole will harm an unborn baby.
Omeprazole can pass into breast milk and may harm a nursing baby.
http://www.drugs.com/omeprazole.html
Your Health
11:50 AM - Public
After you take a course of antibiotics, you may carry resistance genes for years.
This study looks at what happens to the bacteria in the throat and lower intestine of people who took three antibiotics (clarithromycin, metronidazole, and omeprazole) for infections with Helicobacter pylori, the bug that can cause peptic ulcers and stomach cancer. There has recently been a ton of coverage on the effects of antibiotic treatments on the diversity of your native microbiota; generally, as in other studies, the diversity plunged initially and recovered later, but some species never really bounced back, including some species that are known to be relevant to human health. But some of the findings here were more alarming.
The bacteria that survived the treatment were either species that are just not affected by the drugs they used or were individuals of susceptible species that carried genes for resistance. The researchers looked for a gene called _erm_B. This gene encodes resistance to macrolides, a class of drugs that includes clarithromycin. And they found it. After treatment, the amount of this gene in the normal gut bacteria jumped 3 to 5 orders of magnitude above the (very low) baseline level. Four years out, these patients were still carrying the gene at levels 1000 times higher than they had before treatment.
Antibiotic resistance in friendly bacteria is a big deal, not because these bacteria are going to turn on you, but because bacteria are promiscuous. They trade genes all the time, even among distantly related species. So next time these patients have an infection, the invading bugs could pick up the resistance gene from their native microbiota, and then clarithromycin (or any other macrolide) won't work. Obviously, this is a problem. People who take antibiotics frequently may become resistance reservoirs. The more different drugs you've taken, the more resistance genes may be available for the pathogenic bacteria to pick up, the more new antibiotics you will need for the next infection.
The answer, as ever, is careful, restricted use of antibiotics. Prescriptions need to be as pathogen-specific as possible, and, of course, no one should be getting antibiotics they don't really need. When physicians do write prescriptions, they need to consider the patient's history; if they've gotten one drug type recently, it may not work this time.
The long-term persistence of the resistance genes brings up more potential problems. The subjects weren't followed past the 4-year mark, but the gene didn't seem to be going away. Maybe doctors need to consider not just an individual's history, but also their other potential sources of resistance genes -- what about their dogs, or children, or spouses? Ideally, we'd have targeted therapies that only take out the pathogenic bacteria and/or processes to check for the presence of resistance genes before prescription happens. But for now, the best we can do is to be conservative and cautious.
Your Health
11:49 AM - Public
women who had taken them at least three or four times a week over a two-year period were 35 per cent more at risk of suffering hip fractures.
Read more: http://www.dailymail.co.uk/health/article-2094622/Heartburn-pills-taken-women-raise-risk-hip-fractures.html
Read more: http://www.dailymail.co.uk/health/article-2094622/Heartburn-pills-taken-women-raise-risk-hip-fractures.html
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